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Target
Sodium- and chloride-dependent betaine transporter
Ligand
BDBM50000106
Substrate
n/a
Meas. Tech.
ChEMBL_177939 (CHEMBL785010)
IC50
>300000±n/a nM
Citation
 Jacobsen, P; Labouta, IM; Schaumburg, K; Falch, E; Krogsgaard-Larsen, P Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors. J Med Chem 25:1157-62 (1982) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent betaine transporter
Synonyms:
Na(+)/Cl(-) betaine/GABA transporter | S6A12_RAT | Slc6a12 | Sodium- and chloride-dependent betaine transporter | Solute carrier family 6 member 12
Type:
PROTEIN
Mol. Mass.:
69749.57
Organism:
Rattus norvegicus
Description:
ChEMBL_105007
Residue:
614
Sequence:
MDRKVTVHEDGCPVVSWVPEEGEMMDQKDKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNYSSTRAASYSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMAQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFLMLLFLGLDSQFVCMECLVTASMDMFPQQLRKRGRRELLILAVAIVCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYIYPSWGYSIGWLLAFSSMACVPLFIIITLLKTQGSFKKRLQRLITPDPSLPQPGRRSPQDGSSAQNCSTSPVKQELIAWEKETHL
  
Inhibitor
Name:
BDBM50000106
Synonyms:
4-CARBOXYPIPERIDINE | CHEMBL279998 | Piperidine-4-carboxylic acid | Piperidine-4-carboxylic acid (Isonipecotic acid) | Piperidine-4-carboxylic acid(isonipecotic acid)
Type:
Small organic molecule
Emp. Form.:
C6H11NO2
Mol. Mass.:
129.157
SMILES:
OC(=O)C1CCNCC1
Structure:
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