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Target
Phosphatidylinositol 4-kinase type 2-alpha
Ligand
BDBM14487
Substrate
n/a
Meas. Tech.
ChEMBL_152904 (CHEMBL758627)
IC50
30300±n/a nM
Citation
 Young, RC; Jones, M; Milliner, KJ; Rana, KK; Ward, JG Purine derivatives as competitive inhibitors of human erythrocyte membrane phosphatidylinositol 4-kinase. J Med Chem 33:2073-80 (1990) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 4-kinase type 2-alpha
Synonyms:
Phosphatidylinositol 4-kinase type 2-alpha | Phosphatidylinositol 4-kinase type II-alpha | P4K2A_HUMAN | PI4K2A
Type:
PROTEIN
Mol. Mass.:
54030.26
Organism:
Human
Description:
ChEMBL_104812
Residue:
479
Sequence:
MDETSPLVSPERAQPPDYTFPSGSGAHFPQVPGGAVRVAAAAGSGPSPPGSPGHDRERQPLLDRARGAAAQGQTQTVAAQAQALAAQAAAAAHAAQAHRERNEFPEDPEFEAVVRQAELAIERCIFPERIYQGSSGSYFVKDPQGRIIAVFKPKNEEPYGHLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDCPMDSSSSRDTDWVVVKEPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
  
Inhibitor
Name:
BDBM14487
Synonyms:
[U-14C]adenosine | CHEMBL477 | cid_60961 | (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol | N6-Methylado | cid_191 | Adenine-beta-D-arabinofuranoside | Adenosine
Type:
Nucleoside or nucleotide
Emp. Form.:
C10H13N5O4
Mol. Mass.:
267.10
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Structure:
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