Reaction Details Report a problem with these data
Target
Melatonin receptor type 1A/1B/1C
Ligand
BDBM50043289
Substrate
n/a
Meas. Tech.
ChEMBL_104761 (CHEMBL710993)
Ki
0.340000±n/a nM
Citation
 Copinga, S; Tepper, PG; Grol, CJ; Horn, AS; Dubocovich, ML 2-Amido-8-methoxytetralins: a series of nonindolic melatonin-like agents. J Med Chem 36:2891-8 (1993) [PubMed]  Article 
Target
Name:
Melatonin receptor type 1A/1B/1C
Synonyms:
Melatonin receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 104753
Components:
This complex has 3 components.
Component 1
Name:
Melatonin receptor type 1A
Synonyms:
CKA | MTR1A_CHICK | Mel-1A-R | Mel1a receptor | Melatonin receptor type 1A
Type:
PROTEIN
Mol. Mass.:
39911.03
Organism:
Gallus gallus
Description:
ChEMBL_104739
Residue:
353
Sequence:
MRANGSELNGTVLPRDPPAEGSPRRPPWVTSTLATILIFTIVVDLLGNLLVILSVYRNKKLRNAGNIFVVSLAIADLVVAIYPYPLVLTSVFHNGWNLGYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVGLIWVLTVVAIVPNLFVGSLQYDPRIYSCTFAQSVSSAYTIAVVFFHFILPIAIVTYCYLRIWILVIQVRRRVKPDNNPRLKPHDFRNFVTMFVVFVLFAVCWAPLNFIGLAVAVDPETIIPRIPEWLFVSSYYMAYFNSCLNAIIYGLLNQNFRREYKKIVVSFCTAKAFFQDSSNDAADRIRSKPSPLITNNNQVKVDSV
  
Component 2
Name:
Melatonin receptor type 1B
Synonyms:
MEL-1B-R | MTR1B_CHICK | Melatonin | Melatonin receptor | Melatonin receptor type 1B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
33012.73
Organism:
Chick
Description:
Melatonin 0 Chick::P51050
Residue:
289
Sequence:
GNAFVVSLALADLVVALYPYPLVLLAIFHNGWTLGEMHCKVSGFVMGLSVIGSIFNITAIAINRYCYICHSFAYDKVYSCWNTMLYVSLIWVLTVIATVPNFFVGSLKYDPRIYSCTFVQTASSYYTIAVVVIHFIVPITVVSFCYLRIWVLVLQVRRRVKSETKPRLKPSDFRNFLTMFVVFVIFAFCWAPLNFIGLAVAINPSEMAPKVPEWLFIISYFMAYFNSCLNAIIYGLLNQNFRNEYKRILMSLWMPRLFFQDTSKGGTDGQKSKPSPALNNNDQMKTDTL
  
Component 3
Name:
Melatonin receptor type 1C
Synonyms:
CKB | MTR1C_CHICK | Mel-1C-R | Mel1c receptor | Melatonin receptor type 1C
Type:
PROTEIN
Mol. Mass.:
38595.98
Organism:
Gallus gallus
Description:
ChEMBL_104739
Residue:
346
Sequence:
MERPGSNGSCSGCRLEGGPAARAASGLAAVLIVTIVVDVLGNALVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILSAIFHNGWTMGNIHCQISGFLMGLSVIGSIFNITAIAINRYCYICHSLRYDKLFNLKNTCCYICLTWTLTVVAIVPNFFVGSLQYDPRIYSCTFAQTVSTSYTITVVVVHFIVPLSIVTFCYLRIWILVIQVKHRVRQDCKQKIRAADIRNFLTMFVVFVLFAVCWGPLNFIGLAVSINPSKVQPHIPEWLFVLSYFMAYFNSCLNAVIYGLLNQNFRKEYKRILLMLRTPRLLFIDVSKGGTEGLKSKPSPAVTNNNQAEIHL
  
Inhibitor
Name:
BDBM50043289
Synonyms:
CHEMBL34730 | N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide | N-[2-(6-Chloro-5-methoxy-1H-indol-3-yl)-ethyl]-acetamide(6-Chloromelatonin) | melatonin, 6-Chloro
Type:
Small organic molecule
Emp. Form.:
C13H15ClN2O2
Mol. Mass.:
266.723
SMILES:
COc1cc2c(CCNC(C)=O)c[nH]c2cc1Cl
Structure:
Search PDB for entries with ligand similarity: