Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50231466
Substrate
n/a
Meas. Tech.
ChEMBL_1645327 (CHEMBL3994256)
Ki
>10000±n/a nM
Citation
 Liu, T; Wan, Y; Liu, R; Ma, L; Li, M; Fang, H Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. Bioorg Med Chem 25:1939-1948 (2017) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50231466
Synonyms:
CHEMBL4088176
Type:
Small organic molecule
Emp. Form.:
C40H35ClN4O7S
Mol. Mass.:
751.247
SMILES:
CCCOc1ccc(C[C@H](NC(=O)c2cn(Cc3ccc(cc3)-c3ccc(Cl)cc3)c3ccccc23)C(=O)NS(=O)(=O)c2ccc(cc2)[N+]([O-])=O)cc1 |r|
Structure:
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