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Target
Mitogen-activated protein kinase 3
Ligand
BDBM50232019
Substrate
n/a
Meas. Tech.
ChEMBL_1645899 (CHEMBL3994955)
IC50
8700±n/a nM
Citation
 Chen, Y; Zheng, Y; Jiang, Q; Qin, F; Zhang, Y; Fu, L; He, G Integrated bioinformatics, computational and experimental methods to discover novel Raf/extracellular-signal regulated kinase (ERK) dual inhibitors against breast cancer cells. Eur J Med Chem 127:997-1011 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 3
Synonyms:
ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Homo sapiens (Human)
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
  
Inhibitor
Name:
BDBM50232019
Synonyms:
CHEMBL4088518
Type:
Small organic molecule
Emp. Form.:
C23H28N6O4
Mol. Mass.:
452.5062
SMILES:
Cc1cc(Oc2cc(ncn2)N2CCOCC2)ccc1NC(=O)Nc1cc(on1)C(C)(C)C
Structure:
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