Reaction Details Report a problem with these data
Target
Nucleoside diphosphate kinase B
Ligand
BDBM50233219
Substrate
n/a
Meas. Tech.
ChEMBL_1649938 (CHEMBL3999072)
Kd
1800±n/a nM
Citation
 Shan, C; Yan, JW; Wang, YQ; Che, T; Huang, ZL; Chen, AC; Yao, PF; Tan, JH; Li, D; Ou, TM; Gu, LQ; Huang, ZS Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex. J Med Chem 60:1292-1308 (2017) [PubMed]  Article 
Target
Name:
Nucleoside diphosphate kinase B
Synonyms:
2.7.13.3 | 2.7.4.6 | C-myc purine-binding transcription factor PUF | Histidine protein kinase NDKB | NDK B | NDKB_HUMAN | NDP kinase B | NM23B | NME2 | Nucleoside diphosphate kinase B | nm23-H2
Type:
PROTEIN
Mol. Mass.:
17301.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_10050
Residue:
152
Sequence:
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
  
Inhibitor
Name:
BDBM50233219
Synonyms:
CHEMBL4105151
Type:
Small organic molecule
Emp. Form.:
C32H40FN7O3
Mol. Mass.:
589.7035
SMILES:
CN1CCN(CC1)c1cc2nc3\C(CCn3c(=O)c2cc1F)=C\c1ccc(NC(=O)CCN2CCN(CCO)CC2)cc1
Structure:
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