Reaction Details Report a problem with these data
Target
Amino acid transporter
Ligand
BDBM50234287
Substrate
n/a
Meas. Tech.
ChEMBL_1652638 (CHEMBL4001893)
Ki
77000±n/a nM
Citation
 Singh, K; Tanui, R; Gameiro, A; Eisenberg, G; Colas, C; Schlessinger, A; Grewer, C Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2. Bioorg Med Chem Lett 27:398-402 (2017) [PubMed]  Article 
Target
Name:
Amino acid transporter
Synonyms:
Amino acid transporter | Slc1a5
Type:
PROTEIN
Mol. Mass.:
56758.53
Organism:
Rattus norvegicus
Description:
ChEMBL_109757
Residue:
539
Sequence:
MAVDPPKADPKGVVAVDPTANCGSGLKSREDQGAKAGGCCSSRDQVCRCLRANLLVLLTVAAAVAGVVLGLGVSAAGGAEALGHARFTAFAFPGELLLRLLEMIILPLVVCSLIGGAASLDPSALGRLGAWALLFFLVTTLLSSALGVALALALKPGAAFAAINSSVVDSSVHRAPTKEVLDSFLELLRNMFPSNLVSASAAFRIPCGACPQRSNATMDQPHCEMKMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSFNDATMVLVSWIMWYAPIGILFLVAGKIVEMKDIRQLFIGLGKYIVCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFILPIGATVNMDGAALFQCVAAVFIAQLNGMSLDFVKIITILVTATASSVGAAGIPAGGVLTLAIILEAISLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSSEPELIQVKNDVSLKPLPLATEEGNPLLKQCREPSGDSSATCEKESVM
  
Inhibitor
Name:
BDBM50234287
Synonyms:
CHEMBL4100876
Type:
Small organic molecule
Emp. Form.:
C13H15ClF3NO2
Mol. Mass.:
309.712
SMILES:
Cl.OC(=O)[C@@H]1C[C@@H](Cc2cccc(c2)C(F)(F)F)CN1 |r|
Structure:
Search PDB for entries with ligand similarity: