Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50011294
Substrate
n/a
Meas. Tech.
ChEMBL_1654445 (CHEMBL4003811)
Ki
5000±n/a nM
Citation
 Basu, S; Barawkar, DA; Thorat, S; Shejul, YD; Patel, M; Naykodi, M; Jain, V; Salve, Y; Prasad, V; Chaudhary, S; Ghosh, I; Bhat, G; Quraishi, A; Patil, H; Ansari, S; Menon, S; Unadkat, V; Thakare, R; Seervi, MS; Meru, AV; De, S; Bhamidipati, RK; Rouduri, SR; Palle, VP; Chug, A; Mookhtiar, KA Design, Synthesis of Novel, Potent, Selective, Orally Bioavailable Adenosine A J Med Chem 60:681-694 (2017) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50011294
Synonyms:
A2A | Ro-4494351 | Ro-4494351-002 | Ro-4494351000 | SYN-115 | TOZADENANT
Type:
Small organic molecule
Emp. Form.:
C19H26N4O4S
Mol. Mass.:
406.499
SMILES:
COc1ccc(N2CCOCC2)c2sc(NC(=O)N3CCC(C)(O)CC3)nc12
Structure:
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