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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50235175
Substrate
n/a
Meas. Tech.
ChEMBL_1654821 (CHEMBL4004187)
IC50
983±n/a nM
Citation
 Hao, X; Han, Z; Li, Y; Li, C; Wang, X; Zhang, X; Yang, Q; Ma, B; Zhu, C Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity. Bioorg Med Chem Lett 27:887-892 (2017) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50235175
Synonyms:
CHEMBL4061585
Type:
Small organic molecule
Emp. Form.:
C20H20N2O6
Mol. Mass.:
384.3826
SMILES:
COc1ccc2n(CC(O)=O)c(=O)c(CCc3ccc(O)c(OC)c3)nc2c1
Structure:
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