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Target
Cyclin-A2
Ligand
BDBM50235348
Substrate
n/a
Meas. Tech.
ChEMBL_1655488 (CHEMBL4004958)
IC50
3.0±n/a nM
Citation
 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem 60:1746-1767 (2017) [PubMed]  Article 
Target
Name:
Cyclin-A2
Synonyms:
CCNA2 | CCNA2_BOVIN | Cyclin-A | Cyclin-A2
Type:
PROTEIN
Mol. Mass.:
48258.58
Organism:
Bos taurus
Description:
ChEMBL_117723
Residue:
430
Sequence:
MLGSSAHGPAAREAGSAVTLQQTAFQEDQENVNPEKAAPAQQPRTRAGLAVLRAGNSRGPAPQRPKTRRVAPLKDLPINDEYVPVPPWKANNKQPAFTIHVDEAEEEIQKRPTESKKSESEDVLAFNSAVTLPGPRKPLAPLDYPMDGSFESPHTMEMSVVLEDEKPVSVNEVPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLAFDLAAPTINQFLTQYFLHQQPANCKVESLAMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLETLKPCLLDLHQTYLRAPQHAQQSIREKYKNSKYHGVSLLNPPETLNV
  
Inhibitor
Name:
BDBM50235348
Synonyms:
CHEMBL4078988
Type:
Small organic molecule
Emp. Form.:
C15H18N6O3S
Mol. Mass.:
362.407
SMILES:
CC(C)COc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc2[nH]cnc12
Structure:
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