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Target
Cyclin-dependent kinase 2
Ligand
BDBM50235359
Substrate
n/a
Meas. Tech.
ChEMBL_1655478 (CHEMBL4004948)
IC50
0.800000±n/a nM
Citation
 Coxon, CR; Anscombe, E; Harnor, SJ; Martin, MP; Carbain, B; Golding, BT; Hardcastle, IR; Harlow, LK; Korolchuk, S; Matheson, CJ; Newell, DR; Noble, ME; Sivaprakasam, M; Tudhope, SJ; Turner, DM; Wang, LZ; Wedge, SR; Wong, C; Griffin, RJ; Endicott, JA; Cano, C Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem 60:1746-1767 (2017) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50235359
Synonyms:
CHEMBL4088242
Type:
Small organic molecule
Emp. Form.:
C15H19N5O4S
Mol. Mass.:
365.407
SMILES:
CC[C@@H](C)Oc1nc(Nc2ccc(cc2)S(N)(=O)=O)nc(N)c1C=O |r|
Structure:
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