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Target
Dihydrofolate reductase
Ligand
BDBM15339
Substrate
n/a
Meas. Tech.
ChEMBL_1657492 (CHEMBL4006962)
IC50
1.8±n/a nM
Citation
 Sainas, S; Pippione, AC; Giorgis, M; Lupino, E; Goyal, P; Ramondetti, C; Buccinną, B; Piccinini, M; Braga, RC; Andrade, CH; Andersson, M; Moritzer, AC; Friemann, R; Mensa, S; Al-Kadaraghi, S; Boschi, D; Lolli, ML Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem 129:287-302 (2017) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM15339
Synonyms:
6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid | 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid | Biphenquinate | Brequinar | US20240034730, Compound Brequinar
Type:
Small organic molecule
Emp. Form.:
C23H15F2NO2
Mol. Mass.:
375.3675
SMILES:
Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
Structure:
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