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Target
Polycomb protein EED
Ligand
BDBM172038
Substrate
n/a
Meas. Tech.
ChEMBL_1658554 (CHEMBL4008166)
IC50
2±n/a nM
Citation
 Huang, Y; Zhang, J; Yu, Z; Zhang, H; Wang, Y; Lingel, A; Qi, W; Gu, J; Zhao, K; Shultz, MD; Wang, L; Fu, X; Sun, Y; Zhang, Q; Jiang, X; Zhang, J; Zhang, C; Li, L; Zeng, J; Feng, L; Zhang, C; Liu, Y; Zhang, M; Zhang, L; Zhao, M; Gao, Z; Liu, X; Fang, D; Guo, H; Mi, Y; Gabriel, T; Dillon, MP; Atadja, P; Oyang, C Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem 60:2215-2226 (2017) [PubMed]  Article 
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM172038
Synonyms:
US10155002, Compound 44 | US10647700, Compound EPZ6438 | US11052093, Compound 143 | US11535629, Compound Control A | US9090562, 143 | US9090562, 44 | US9394283, 1
Type:
Small organic molecule
Emp. Form.:
C34H44N4O4
Mol. Mass.:
572.7376
SMILES:
CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
Structure:
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