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Target
Inosine triphosphate pyrophosphatase
Ligand
BDBM50236118
Substrate
n/a
Meas. Tech.
ChEBML_1658779
IC50
>100000±n/a nM
Citation
 Llona-Minguez, S; Höglund, A; Wiita, E; Almlöf, I; Mateus, A; Calderón-Montaño, JM; Cazares-Körner, C; Homan, E; Loseva, O; Baranczewski, P; Jemth, AS; Häggblad, M; Martens, U; Lundgren, B; Artursson, P; Lundbäck, T; Jenmalm Jensen, A; Warpman Berglund, U; Scobie, M; Helleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem 60:2148-2154 (2017) [PubMed]  Article 
Target
Name:
Inosine triphosphate pyrophosphatase
Synonyms:
3.6.1.9 | C20orf37 | ITPA | ITPA_HUMAN | ITPase | Inosine triphosphatase | Inosine triphosphate pyrophosphatase | NTPase | Non-canonical purine NTP pyrophosphatase | Non-standard purine NTP pyrophosphatase | Nucleoside-triphosphate diphosphatase | Nucleoside-triphosphate pyrophosphatase | Putative oncogene protein hlc14-06-p
Type:
PROTEIN
Mol. Mass.:
21443.41
Organism:
Homo sapiens (Human)
Description:
ChEMBL_117393
Residue:
194
Sequence:
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA
  
Inhibitor
Name:
BDBM50236118
Synonyms:
CHEMBL4065181
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2S2
Mol. Mass.:
344.411
SMILES:
COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1cccs1
Structure:
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