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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50237477
Substrate
n/a
Meas. Tech.
ChEMBL_1660124 (CHEMBL4009736)
IC50
8.2±n/a nM
Citation
 Hoang, VH; Tran, PT; Cui, M; Ngo, VT; Ann, J; Park, J; Lee, J; Choi, K; Cho, H; Kim, H; Ha, HJ; Hong, HS; Choi, S; Kim, YH; Lee, J Discovery of Potent Human Glutaminyl Cyclase Inhibitors as Anti-Alzheimer's Agents Based on Rational Design. J Med Chem 60:2573-2590 (2017) [PubMed]  Article 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50237477
Synonyms:
CHEMBL4062645
Type:
Small organic molecule
Emp. Form.:
C24H38N6O2S
Mol. Mass.:
474.663
SMILES:
COc1cc(NC(=S)NCCCn2cncc2C)ccc1OCCCCN1CCN(C)CC1
Structure:
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