Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50237774
Substrate
n/a
Meas. Tech.
ChEMBL_1661883 (CHEMBL4011495)
Ki
1260±n/a nM
Citation
 Yu, J; Zhao, LX; Park, J; Lee, HW; Sahu, PK; Cui, M; Moss, SM; Hammes, E; Warnick, E; Gao, ZG; Noh, M; Choi, S; Ahn, HC; Choi, J; Jacobson, KA; Jeong, LS N J Med Chem 60:3422-3437 (2017) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50237774
Synonyms:
CHEMBL4059807
Type:
Small organic molecule
Emp. Form.:
C19H22N6O4Se
Mol. Mass.:
477.38
SMILES:
CNC(=O)[C@H]1[Se][C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3ccccc3OC)ncnc12 |r|
Structure:
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