Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50238499
Substrate
n/a
Meas. Tech.
ChEMBL_1663651 (CHEMBL4013332)
EC50
3±n/a nM
Citation
 Carpenter, JCarpenter, JWang, YWang, YWu, GWu, GFeng, JFeng, JYe, XYYe, XYMorales, CLMorales, CLBroekema, MBroekema, MRossi, KARossi, KAMiller, KJMiller, KJMurphy, BJMurphy, BJWu, GWu, GMalmstrom, SEMalmstrom, SEAzzara, AVAzzara, AVSher, PMSher, PMFevig, JMFevig, JMAlt, AAlt, ABertekap, RLBertekap, RLCullen, MJCullen, MJHarper, TMHarper, TMFoster, KFoster, KLuk, ELuk, EXiang, QXiang, QGrubb, MFGrubb, MFRobl, JARobl, JAWacker, DAWacker, DA Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT J Med Chem 60:6166-6190 (2017) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM50238499
Synonyms:
CHEMBL4100216
Type:
Small organic molecule
Emp. Form.:
C18H15N5
Mol. Mass.:
301.3452
SMILES:
CCn1nc(cc1-c1cccnn1)-c1cccc2cccnc12
Structure:
Search PDB for entries with ligand similarity: