Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50238518
Substrate
n/a
Meas. Tech.
ChEMBL_1663654 (CHEMBL4013335)
EC50
129±n/a nM
Citation
 Carpenter, J; Carpenter, J; Wang, Y; Wang, Y; Wu, G; Wu, G; Feng, J; Feng, J; Ye, XY; Ye, XY; Morales, CL; Morales, CL; Broekema, M; Broekema, M; Rossi, KA; Rossi, KA; Miller, KJ; Miller, KJ; Murphy, BJ; Murphy, BJ; Wu, G; Wu, G; Malmstrom, SE; Malmstrom, SE; Azzara, AV; Azzara, AV; Sher, PM; Sher, PM; Fevig, JM; Fevig, JM; Alt, A; Alt, A; Bertekap, RL; Bertekap, RL; Cullen, MJ; Cullen, MJ; Harper, TM; Harper, TM; Foster, K; Foster, K; Luk, E; Luk, E; Xiang, Q; Xiang, Q; Grubb, MF; Grubb, MF; Robl, JA; Robl, JA; Wacker, DA; Wacker, DA Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT J Med Chem 60:6166-6190 (2017) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50238518
Synonyms:
CHEMBL4083432
Type:
Small organic molecule
Emp. Form.:
C15H12Cl2N2O2S
Mol. Mass.:
355.239
SMILES:
Clc1cccc(-c2nc(cs2)C(=O)N2CC3CC2CO3)c1Cl
Structure:
Search PDB for entries with ligand similarity: