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Target
Interleukin-15
Ligand
BDBM50238647
Substrate
n/a
Meas. Tech.
ChEMBL_1664049 (CHEMBL4013730)
Kd
78000±n/a nM
Citation
 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization. J Med Chem 60:6249-6272 (2017) [PubMed]  Article 
Target
Name:
Interleukin-15
Synonyms:
IL-15 | IL15 | IL15-IL15 receptor | IL15_HUMAN | Interleukin-15
Type:
PROTEIN
Mol. Mass.:
18080.13
Organism:
Homo sapiens
Description:
ChEMBL_117698
Residue:
162
Sequence:
MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
  
Inhibitor
Name:
BDBM50238647
Synonyms:
CHEMBL4066088
Type:
Small organic molecule
Emp. Form.:
C31H42N6O2S
Mol. Mass.:
562.769
SMILES:
Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCCCCCCCC(=O)NC12CC3CC(CC(C3)C1)C2 |THB:35:34:31:37.36.38,35:36:33.34.39:31,38:36:33:39.30.31,38:30:33:37.35.36|
Structure:
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