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Target
Interleukin-2
Ligand
BDBM50238648
Substrate
n/a
Meas. Tech.
ChEBML_1664050
Kd
10500±n/a nM
Citation
 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization. J Med Chem 60:6249-6272 (2017) [PubMed]  Article 
Target
Name:
Interleukin-2
Synonyms:
IL-2 | IL2 | IL2_HUMAN | INN=Aldesleukin | Interleukin-2 | Interleukin-2 (IL-2) | T-cell growth factor | TCGF
Type:
Enzyme
Mol. Mass.:
17630.05
Organism:
Homo sapiens (Human)
Description:
P60568
Residue:
153
Sequence:
MYRMQLLSCIALSLALVTNSAPTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
  
Inhibitor
Name:
BDBM50238648
Synonyms:
CHEMBL4102828
Type:
Small organic molecule
Emp. Form.:
C21H18Cl2N6O2S
Mol. Mass.:
489.378
SMILES:
Cn1c(Cc2nn(C)c(=O)c3ccccc23)nnc1SCC(=O)Nc1ccc(Cl)cc1Cl
Structure:
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