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Target
Interleukin-15
Ligand
BDBM50238652
Substrate
n/a
Meas. Tech.
ChEMBL_1664049 (CHEMBL4013730)
Kd
19600±n/a nM
Citation
 Quéméner, A; Maillasson, M; Arzel, L; Sicard, B; Vomiandry, R; Mortier, E; Dubreuil, D; Jacques, Y; Lebreton, J; Mathé-Allainmat, M Discovery of a Small-Molecule Inhibitor of Interleukin 15: Pharmacophore-Based Virtual Screening and Hit Optimization. J Med Chem 60:6249-6272 (2017) [PubMed]  Article 
Target
Name:
Interleukin-15
Synonyms:
IL-15 | IL15 | IL15-IL15 receptor | IL15_HUMAN | Interleukin-15
Type:
PROTEIN
Mol. Mass.:
18080.13
Organism:
Homo sapiens
Description:
ChEMBL_117698
Residue:
162
Sequence:
MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
  
Inhibitor
Name:
BDBM50238652
Synonyms:
CHEMBL4066271
Type:
Small organic molecule
Emp. Form.:
C29H36N6O4S
Mol. Mass.:
564.699
SMILES:
COc1ccc(NC(=O)CCCCCCCSc2nnc(Cc3nn(C)c(=O)c4ccccc34)n2C)c(OC)c1
Structure:
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