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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50238867
Substrate
n/a
Meas. Tech.
ChEMBL_1664430 (CHEMBL4014111)
IC50
2.0±n/a nM
Citation
 Sun, QZ; Sun, QZ; Lin, GF; Lin, GF; Li, LL; Li, LL; Jin, XT; Jin, XT; Huang, LY; Huang, LY; Zhang, G; Zhang, G; Yang, W; Yang, W; Chen, K; Chen, K; Xiang, R; Xiang, R; Chen, C; Chen, C; Wei, YQ; Wei, YQ; Lu, GW; Lu, GW; Yang, SY; Yang, SY Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem 60:6337-6352 (2017) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50238867
Synonyms:
CHEMBL4083249
Type:
Small organic molecule
Emp. Form.:
C24H16FN5O
Mol. Mass.:
409.4151
SMILES:
C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Structure:
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