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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Ligand
BDBM50238867
Substrate
n/a
Meas. Tech.
ChEMBL_1664439 (CHEMBL4014120)
IC50
>10000±n/a nM
Citation
 Sun, QZ; Sun, QZ; Lin, GF; Lin, GF; Li, LL; Li, LL; Jin, XT; Jin, XT; Huang, LY; Huang, LY; Zhang, G; Zhang, G; Yang, W; Yang, W; Chen, K; Chen, K; Xiang, R; Xiang, R; Chen, C; Chen, C; Wei, YQ; Wei, YQ; Lu, GW; Lu, GW; Yang, SY; Yang, SY Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers. J Med Chem 60:6337-6352 (2017) [PubMed]  Article 
Target
Name:
Dual specificity tyrosine-phosphorylation-regulated kinase 3
Synonyms:
DYRK3 | DYRK3_HUMAN | Dual-specificity tyrosine-phosphorylation regulated kinase 3
Type:
PROTEIN
Mol. Mass.:
65747.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508026
Residue:
588
Sequence:
MGGTARGPGRKDAGPPGAGLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGDHTQHFLDGGEMKVEQLFQEFGNRKSNTIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAPKVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLGSKLPPVVGIANKLKANLMSETNGSIPLCSVLPKLIS
  
Inhibitor
Name:
BDBM50238867
Synonyms:
CHEMBL4083249
Type:
Small organic molecule
Emp. Form.:
C24H16FN5O
Mol. Mass.:
409.4151
SMILES:
C[C@@H](c1ccc(F)cc1)n1nnc2cnc3ccc(cc3c12)-c1ccc2ocnc2c1 |r|
Structure:
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