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Target
Death-associated protein kinase 3
Ligand
BDBM50024284
Substrate
n/a
Meas. Tech.
ChEMBL_1664714 (CHEMBL4014510)
IC50
39820±n/a nM
Citation
 Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, J; Li, JY; Yu, LF; Yang, F Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet?-cells from apoptosis. Eur J Med Chem 130:195-208 (2017) [PubMed]  Article 
Target
Name:
Death-associated protein kinase 3
Synonyms:
DAP kinase 3 | DAP-like kinase | DAPK3 | DAPK3_HUMAN | ZIP-kinase | ZIPK
Type:
PROTEIN
Mol. Mass.:
52537.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_586564
Residue:
454
Sequence:
MSTFRQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKFIKKRRLSSSRRGVSREEIEREVNILREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKESLTEDEATQFLKQILDGVHYLHSKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPKRRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFSKVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEALKRQAQEEAKGALLGTSGLKRRFSRLENRYEALAKQVASEMRFVQDLVRALEQEKLQGVECGLR
  
Inhibitor
Name:
BDBM50024284
Synonyms:
CHEMBL3334979
Type:
Small organic molecule
Emp. Form.:
C22H24N2O3S
Mol. Mass.:
396.503
SMILES:
COc1ccc(cc1OC)-c1cnc2scc(NC(=O)C3CCCCC3)c2c1
Structure:
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