Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM274965
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
135±n/a nM
Comments
extracted
Citation
More Info.:
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
Inhibitor
Name:
BDBM274965
Synonyms:
N-((2-(tert-butylcarbamoyl)-5-(3- methoxyphenyl)-1,2,3,4- tetrahydroisoquinolin-8- yl)methyl)isoquinoline-1-carboxamide | US9877957, Example 5
Type:
Small organic molecule
Emp. Form.:
C32H34N4O3
Mol. Mass.:
522.6374
SMILES:
COc1cccc(c1)-c1ccc(CNC(=O)c2nccc3ccccc23)c2CN(CCc12)C(=O)NC(C)(C)C