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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM274982
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
214±n/a nM
Comments
extracted
Citation
 Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US9877957 Publication Date 1/30/2018 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM274982
Synonyms:
(R/S)-N2-(tert-butyl)-N8-(2-hydroxy-1-(6- (trifluoromethyl)pyridin-3-yl)ethyl)-5-(3- (trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2,8(1H)-dicarboxamide (mixture of 2 enantiomers) | US9877957, Example 21
Type:
Small organic molecule
Emp. Form.:
C30H30F6N4O3
Mol. Mass.:
608.5746
SMILES:
CC(C)(C)NC(=O)N1CCc2c(C1)c(ccc2-c1cccc(c1)C(F)(F)F)C(=O)N[C@@H](CO)c1ccc(nc1)C(F)(F)F |r|
Structure:
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