Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM275026
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
390±n/a nM
Comments
extracted
Citation
 Imbriglio, J; London, C; Lu, Z; Tata, J; Xiong, Y; You, M; Youm, H Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US9877957 Publication Date 1/30/2018 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM275026
Synonyms:
N2-(tert-butyl)-N8-(1-(imidazo[2,1- b][1,3,4]thiadiazol-6-yl)ethyl)-5-(3- (trifluoromethyl)phenyl)-3,4- dihydroisoquinoline-2,8(1H)-dicarboxamide | US9877957, Example 64
Type:
Small organic molecule
Emp. Form.:
C28H29F3N6O2S
Mol. Mass.:
570.629
SMILES:
CC(NC(=O)c1ccc(-c2cccc(c2)C(F)(F)F)c2CCN(Cc12)C(=O)NC(C)(C)C)c1cn2ncsc2n1
Structure:
Search PDB for entries with ligand similarity: