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Target
Gamma-aminobutyric acid receptor subunit alpha-1
Ligand
BDBM85031
Substrate
n/a
Ki
350±n/a nM
Comments
PDSP_1423
Citation
 Hoogerkamp, A; Arends, RH; Bomers, AM; Mandema, JW; Voskuyl, RA; Danhof, M Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect. J Pharmacol Exp Ther 279:803-12 (1996) [PubMed] 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-1
Synonyms:
Benzodiazepine central | Benzodiazepine receptors | GABA A Benzodiazepine | GABA A Benzodiazepine Type I | GABA A Benzodiazepine Type II | GABA A Benzodiazepine Type IIL | GABA A Benzodiazepine Type IIM | GABA A Benzodiazepine omega1 | GABA A Benzodiazepine omega2 | GABA A Benzodiazepine omega5 | GABA A alpha1 | GABA A anti-Alpha1 | GABA receptor alpha-1 subunit | GABA, Chloride, TBOB | GABA-PICROTOXIN | GBRA1_RAT | Gabra-1 | Gabra1 | TBPS
Type:
Enzyme
Mol. Mass.:
51770.21
Organism:
Rattus norvegicus (Rat)
Description:
P62813
Residue:
455
Sequence:
MKKSRGLSDYLWAWTLILSTLSGRSYGQPSQDELKDNTTVFTRILDRLLDGYDNRLRPGLGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDPLIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKIDRLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
  
Inhibitor
Name:
BDBM85031
Synonyms:
CAS_604-75-1 | NSC_4616 | Oxazepam
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2O2
Mol. Mass.:
286.713
SMILES:
OC1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O |t:2|
Structure:
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