Reaction Details
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G_PROTEIN_RECEP_F1_2 domain-containing protein
Ligand
BDBM85097
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_1670
Citation
Kennett, GA; Wood, MD; Bright, F; Trail, B; Riley, G; Holland, V; Avenell, KY; Stean, T; Upton, N; Bromidge, S; Forbes, IT; Brown, AM; Middlemiss, DN; Blackburn, TP SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 36:609-20 (1997) [PubMed] Article More Info.:
Target
Name:
G_PROTEIN_RECEP_F1_2 domain-containing protein
Synonyms:
5-HT1E | HTR1E
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41350.06
Organism:
C.H.O.
Description:
5-HT1E HTR1E C.H.O.::F6XI83
Residue:
365
Sequence:
MNFTNCTTEASVAIKSKSVTEKMLVSMTLVVITTMTTLLNSAVIIAICTTKKLHQPANYLICSLAVTDLLVAVLVMPLSITYIVMDSWTLGYFVCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAGLMILTVWTISIFISMPPLFWRSHRLLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKTLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFDKINTSVRIPPFDNDLDQAGDRQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSLYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKRLVRCREHS
Inhibitor
Name:
BDBM85097
Synonyms:
CAS_181632-25-7 | CHEMBL14563 | SB 242084
Type:
Small organic molecule
Emp. Form.:
C21H19ClN4O2
Mol. Mass.:
394.854
SMILES:
Cc1cc2CCN(C(=O)Nc3ccc(Oc4cccnc4C)nc3)c2cc1Cl
Structure:
