Reaction Details
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Thromboxane-A synthase
Ligand
BDBM81948
Substrate
n/a
Ki
14±n/a nM
Comments
PDSP_1772
Citation
Kiriyama, M; Ushikubi, F; Kobayashi, T; Hirata, M; Sugimoto, Y; Narumiya, S Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122:217-24 (1997) [PubMed] Article More Info.:
Target
Name:
Thromboxane-A synthase
Synonyms:
Cyp5 | Cyp5a1 | THAS_MOUSE | Tbxas1 | Thromboxane Alpha
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60395.39
Organism:
MOUSE
Description:
Thromboxane Alpha 0 MOUSE::P36423
Residue:
533
Sequence:
MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGIRHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACELLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPETQVPLQLESKSALGPKNGVYIKIVSR
Inhibitor
Name:
BDBM81948
Synonyms:
CAS_89617-02-7 | ONO 11,113 | ONO-11113 | STA2
Type:
Small organic molecule
Emp. Form.:
C21H34O3S
Mol. Mass.:
366.558
SMILES:
CCCCC[C@H](O)\C=C\C1C[C@H]2C[C@H](S2)[C@@H]1C\C=C/CCCC(O)=O |r|
Structure:
