Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Gamma-aminobutyric acid receptor subunit alpha-2
Ligand
BDBM50000687
Substrate
n/a
Ki
8.91±n/a nM
Comments
PDSP_1758
Citation
Ebert, B; Thompson, SA; Saounatsou, K; McKernan, R; Krogsgaard-Larsen, P; Wafford, KA Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors. Mol Pharmacol 52:1150-6 (1997) [PubMed] More Info.:
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)
Type:
Protein
Mol. Mass.:
51338.78
Organism:
Homo sapiens (Human)
Description:
P47869
Residue:
451
Sequence:
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
Inhibitor
Name:
BDBM50000687
Synonyms:
2-(3-Carboxy-propyl)-6-(4-methoxy-phenyl)-2H-pyridazin-3-ylidene-ammonium; bromide(gabazine) | 4-[6-Amino-3-(4-methoxy-phenyl)-6H-pyridazin-1-yl]-butyric acid : bromide | 6-Amino-1-(3-carboxy-propyl)-3-(4-methoxy-phenyl)-pyridazin-1-ium; bromide | CHEMBL303580 | SR 95531
Type:
Small organic molecule
Emp. Form.:
C15H18N3O3
Mol. Mass.:
288.3212
SMILES:
COc1ccc(cc1)-c1ccc(=[NH2+])n(CCCC(O)=O)n1
Structure:
