Reaction Details Report a problem with these data
Target
Sodium-dependent serotonin transporter
Ligand
BDBM50020706
Substrate
n/a
Ki
152±n/a nM
Comments
PDSP_1995
Citation
 Tatsumi, M; Groshan, K; Blakely, RD; Richelson, E Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol 340:249-58 (1997) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50020706
Synonyms:
CHEMBL37744 | ZIMELIDINE | Zimeldine | [3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine | [3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine (Zimelidine) | [3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine(Zimeldine) | cis -[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine;HCl | trans-[3-(4-Bromo-phenyl)-3-pyridin-3-yl-allyl]-dimethyl-amine;C2H4O4
Type:
Small organic molecule
Emp. Form.:
C16H17BrN2
Mol. Mass.:
317.224
SMILES:
CN(C)C\C=C(\c1ccc(Br)cc1)c1cccnc1
Structure:
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