Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM50005257
Substrate
n/a
Ki
21.8±n/a nM
Comments
PDSP_706
Citation
 Nelson, DL; Lucaites, VL; Wainscott, DB; Glennon, RA Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol 359:1-6 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT2B | 5-hydroxytryptamine receptor 2B | 5HT2B_RAT | Htr2b | Serotonin 2b (5-HT2b) receptor | Serotonin receptor 2a and 2b (5HT2A and 5HT2B) | Srl
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53668.47
Organism:
RAT
Description:
5-HT2B HTR2B RAT::P30994
Residue:
479
Sequence:
MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
  
Inhibitor
Name:
BDBM50005257
Synonyms:
(+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (+)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (+/-)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (-)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | (-)2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | 1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine | 2-(2-Methoxy-phenyl)-1-methyl-ethylamine | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((-)-DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((R)-(-)-DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine((S)-(+)-DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine(DOB) | 2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethylamine[R(-)DOB] | 2-(5-Bromo-2,4-dimethoxy-phenyl)-1-methyl-ethylamine | Brolamfetamine | CHEMBL6607 | DOB | Racemic DOB
Type:
Small organic molecule
Emp. Form.:
C11H16BrNO2
Mol. Mass.:
274.154
SMILES:
COc1cc(CC(C)N)c(OC)cc1Br
Structure:
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