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Target
Platelet-derived growth factor receptor beta
Ligand
BDBM3360
Substrate
poly(E,Y)
Meas. Tech.
Kinase Inhibition Assay
IC50
>50000±n/a nM
Citation
 Showalter, HD; Sercel, AD; Leja, BM; Wolfangel, CD; Ambroso, LA; Elliott, WL; Fry, DW; Kraker, AJ; Howard, CT; Lu, GH; Moore, CW; Nelson, JM; Roberts, BJ; Vincent, PW; Denny, WA; Thompson, AM Tyrosine kinase inhibitors. 6. Structure-activity relationships among N- and 3-substituted 2,2'-diselenobis(1H-indoles) for inhibition of protein tyrosine kinases and comparative in vitro and in vivo studies against selected sulfur congeners. J Med Chem 40:413-26 (1997) [PubMed]  Article 
Target
Name:
Platelet-derived growth factor receptor beta
Synonyms:
2.7.10.1 | Beta platelet-derived growth factor receptor | Beta-type platelet-derived growth factor receptor | CD140 antigen-like family member B | CD140b antigen | CD_antigen=CD140b | PDGF-R-beta | PDGFR-1 | PDGFR-beta | PGFRB_MOUSE | Pdgfr | Pdgfr1 | Pdgfrb | Platelet-Derived Growth Factor Receptor, beta | Platelet-derived growth factor receptor | Platelet-derived growth factor receptor 1
Type:
Enzyme
Mol. Mass.:
122771.00
Organism:
Mus musculus (mouse)
Description:
P05622
Residue:
1098
Sequence:
MGLPGVIPALVLRGQLLLSVLWLLGPQTSRGLVITPPGPEFVLNISSTFVLTCSGSAPVMWEQMSQVPWQEAAMNQDGTFSSVLTLTNVTGGDTGEYFCVYNNSLGPELSERKRIYIFVPDPTMGFLPMDSEDLFIFVTDVTETTIPCRVTDPQLEVTLHEKKVDIPLHVPYDHQRGFTGTFEDKTYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQTVVRQGESITIRCIVMGNDVVNFQWTYPRMKSGRLVEPVTDYLFGVPSRIGSILHIPTAELSDSGTYTCNVSVSVNDHGDEKAINISVIENGYVRLLETLGDVEIAELHRSRTLRVVFEAYPMPSVLWLKDNRTLGDSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQVNVPVRVLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGGDSQEVTVVPHSLPFKVVVISAILALVVLTVISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPVQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDMSKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLSYTDLVGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHSLRSPLDTSSVLYTAVQPNESDNDYIIPLPDPKPDVADEGLPEGSPSLASSTLNEVNTSSTISCDSPLELQEEPQQAEPEAQLEQPQDSGCPGPLAEAEDSFL
  
Inhibitor
Name:
BDBM3360
Synonyms:
(2R)-N-benzyl-3-[2-({3-[(2R)-2-(benzylcarbamoyl)-2-(2,2,2-trifluoroacetamido)ethyl]-1H-indol-2-yl}diselanyl)-1H-indol-3-yl]-2-(2,2,2-trifluoroacetamido)propanamide | [R-(R*,R*)]-2,2 -diselenobis[N-(phenylmethyl)-alpha-[(trifluoroacetyl)amino]-1H-indole-3-propanamide] | diselenobis(1H-indole) deriv. 32a
Type:
Small organic molecule
Emp. Form.:
C40H34F6N6O4Se2
Mol. Mass.:
934.65
SMILES:
FC(F)(F)C(=O)N[C@H](Cc1c([Se][Se]c2[nH]c3ccccc3c2C[C@@H](NC(=O)C(F)(F)F)C(=O)NCc2ccccc2)[nH]c2ccccc12)C(=O)NCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
poly(E,Y)
Synonyms:
n/a
Type:
Random Polymer
Mol. Mass.:
358.43
Organism:
n/a
Description:
poly[(glu)4(tyr)l].
Residue:
3
Sequence:
NA