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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM85763
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
1.0e+4±n/a nM
Citation
 Rochais, C; Lescot, E; Lisowski, V; Lepailleur, A; Santos, JS; Bureau, R; Dallemagne, P; Meijer, L; Rault, S Synthesis and biological evaluation of thienopyrrolizines, a new family of CDK/GSK-3 inhibitors. J Enzyme Inhib Med Chem 19:585-93 (2004) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM85763
Synonyms:
Thienopyrrolizine derivative, 4j
Type:
Small organic molecule
Emp. Form.:
C17H7NO7S
Mol. Mass.:
369.306
SMILES:
[O-]C(=O)Oc1ccc(cc1OC([O-])=O)-c1csc2C(=O)c3cccn3-c12
Structure:
Search PDB for entries with ligand similarity: