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Target
Macrophage colony-stimulating factor 1 receptor
Ligand
BDBM276745
Substrate
n/a
Meas. Tech.
c-Fms Enzyme Assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
2.50±n/a nM
Comments
extracted
Citation
 Chen, J; Donahue, M; Lim, H; Lin, R; Salter, R; Wu, J; Gong, Y Substituted pyridine derivatives useful as c-fms kinase inhibitors US Patent  US10071991 Publication Date 9/11/2018 
Target
Name:
Macrophage colony-stimulating factor 1 receptor
Synonyms:
CD_antigen: CD115 | CSF-1 receptor | CSF-1-R | CSF-1R | CSF1R_RAT | Csf1r | Csfmr | Fms | M-CSF-R | Proto-oncogene c-Fms
Type:
Enzyme Catalytic Domain
Mol. Mass.:
109259.61
Organism:
Rattus norvegicus (Rat)
Description:
Q00495
Residue:
978
Sequence:
MELGPPLVLLLATVWHGQGAPVIEPSGPELVVEPGETVTLRCVSNGSVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTELEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQVLRKTVYFFSAWRGFIIRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLEPSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDAGIYSCVASNDVGTRTATMNFQVVESAYLNLTSEQSLLQEVSVGDSLILTVHADAYPSIQHYNWTYLGPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVWNDTHPEVLSQKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEPSRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESILYCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQICFLLQEQARLERRDQDYANLPSSGGSSGSDSGGGSSGGSSSEPEEESSSEHLACCEPGDIAQPLLQPNNYQFAC
  
Inhibitor
Name:
BDBM276745
Synonyms:
US10071991, Compound (I-M2-2R,4S) | US10800764, Compound (I-M2-2R-4S) | US11214566, Compound (I-M2-2R,4S)
Type:
Small organic molecule
Emp. Form.:
C27H33N5O4
Mol. Mass.:
491.582
SMILES:
CC1(C)CCC(=CC1)c1nc(ccc1NC(=O)c1nc(c[nH]1)C#N)[C@H]1CC(C)(C)O[C@](C)(C1)C(O)=O |r,c:5|
Structure:
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