Reaction Details
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Calcitonin gene-related peptide type 1 receptor
Ligand
BDBM85839
Substrate
n/a
Ki
50.7±n/a nM
Comments
PDSP_2307
Citation
Rorabaugh, BR; Scofield, MA; Smith, DD; Jeffries, WB; Abel, PW Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 299:1086-94 (2001) [PubMed] More Info.:
Target
Name:
Calcitonin gene-related peptide type 1 receptor
Synonyms:
CALCRL | CALRL_PIG | CGRP | CGRPR
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53657.10
Organism:
PIG
Description:
CGRP 0 PIG::Q8WN93
Residue:
462
Sequence:
MEKKYILYFLFLLPFFMILVIAETEEENPDDLIQLTVTRNKIMTAQYECYQKIMQDPIQQTEGIYCNRTWDGWLCWNDVAAGTESMQHCPDYFQDFDPSEKVTKICDQDGNWFRHPESNRTWTNYTQCNINTHEKVQTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQALVATNPVSCKVFQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAVARRLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKIAEEVYDYIMHILVHYQGLLVSTIYCFFNGEVQAILRRNWNQYKIQFGNSFSHSDALRSASYTVSTISDGAGYSHDYPSEHLNGKSIHDMENIVIKPEKLYD
Inhibitor
Name:
BDBM85839
Synonyms:
[Pro34,Phe35]h alpha-CGRP27-37
Type:
Small organic molecule
Emp. Form.:
C46H66N11O11
Mol. Mass.:
949.0833
SMILES:
[H][N]1([#6]-[#6]-[#6]-[#6@H]1-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](-[#7])=O)[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@@H]-1-[#6]-[#6]-[#6]-[#7]-1)-[#6@@H](-[#6])-[#8])-[#6](-[#6])-[#6]
Structure:
