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Target
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Ligand
BDBM84745
Substrate
n/a
Ki
1000±n/a nM
Comments
PDSP_763
Citation
 Bymaster, FP; Dreshfield-Ahmad, LJ; Threlkeld, PG; Shaw, JL; Thompson, L; Nelson, DL; Hemrick-Luecke, SK; Wong, DT Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 25:871-80 (2001) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Synonyms:
Inositol Triphosphate | Inppl1 | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | SHIP2_RAT | Ship2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
139139.35
Organism:
RAT
Description:
Inositol Triphosphate 0 RAT::Q9WVR3
Residue:
1257
Sequence:
MASVCGAPSPGGALGSQAPAWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDVEDEKPPLPPRSGSTSISVPAGPSSPLPAPETPTTPAAESTPNGLSTVSHEYLKGSYGLDLEAVRGGASNLPHLTRTLVTSCRRLHSEVDKVLSGLEILSKVFDQQSSPMVTRLLQQQSLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPLQPSIRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTHDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKALDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTTRRNQNYLDILRLLSLGDRQLSAFDISLRFTHLFWFGDLNYRLDMDIQEILNYISRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDDTGAKSKAPSVLRGSQEHRSGSRKPTSTEASCPLSKLFEEPEKPPPTGRPPAPPRAVPREESLNPRLKSEGTPEQEGVAAPPPKNSFNNPAYYVLEGVPHQLLPLEPTSFARAPIPPTTKNKVAITVPAPQLGRHRTPRVGEGSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSVGEARGPPPPKAHPRPPLPPGTSPASTFLEEVASADDRSCSVLQMAKTLSEVDYSPGPGRSALLPNPLELQLPRGPSDYGRPLSFPPPRIRESIQEDLAEEAPCPQGGRASGLGEAGMGAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
  
Inhibitor
Name:
BDBM84745
Synonyms:
CAS_136434-34-9 | DULOXETINE | LY-248686 | LY248686 | USRE49340, Rank 5
Type:
Small organic molecule
Emp. Form.:
C18H19NOS
Mol. Mass.:
297.415
SMILES:
CNCC[C@H](Oc1cccc2ccccc12)c1cccs1 |r|
Structure:
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