Reaction Details
Report a problem with these data
Report a problem with these dataTarget
neuronal acetylcholine receptor subunit alpha-2
Ligand
BDBM86042
Substrate
n/a
Ki
3.3±n/a nM
Comments
PDSP_2905
Citation
Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther 302:1246-52 (2002) [PubMed] Article More Info.:
Target
Name:
neuronal acetylcholine receptor subunit alpha-2
Synonyms:
Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59160.03
Organism:
Xenopus
Description:
A0A6I8T284
Residue:
510
Sequence:
MENCMGGTLSILCWMITFTTVSCMERTRTHAEERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPADYDNVTSIRVPSEMIWIPDIVLYNNADGEFAITHMTKAHLFHNGKVKWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDKAWLDLESMERNVDLKDYWESGEWAIVNAVGKYNSKKYDCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHKMPLWVRSVFLDHIPRWLFMKRPPAPVEEVVSQYDAPELKLSTSKYWMETDVDDKWAEPEAELQTCHVRHMTTHNQSLQYRYDYNHHVSGGQSQTPRHSSTETAESSFLLSPSVLKALEGVHYIANHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPFLAGMI
Inhibitor
Name:
BDBM86042
Synonyms:
NEP
Type:
Small organic molecule
Emp. Form.:
C11H14N2
Mol. Mass.:
174.2423
SMILES:
C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Structure:
