Reaction Details
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neuronal acetylcholine receptor subunit alpha-2
Ligand
BDBM86045
Substrate
n/a
Ki
3.5±n/a nM
Comments
PDSP_2904
Citation
Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther 302:1246-52 (2002) [PubMed] Article More Info.:
Target
Name:
neuronal acetylcholine receptor subunit alpha-2
Synonyms:
Cholinergic, Nicotinic Alpha2Beta2 | Cholinergic, Nicotinic Alpha2Beta4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59160.03
Organism:
Xenopus
Description:
A0A6I8T284
Residue:
510
Sequence:
MENCMGGTLSILCWMITFTTVSCMERTRTHAEERLFKRLFTGYNRWSRPVPNTSDVVIVKFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNPADYDNVTSIRVPSEMIWIPDIVLYNNADGEFAITHMTKAHLFHNGKVKWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDKAWLDLESMERNVDLKDYWESGEWAIVNAVGKYNSKKYDCCTEIYPDITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHKMPLWVRSVFLDHIPRWLFMKRPPAPVEEVVSQYDAPELKLSTSKYWMETDVDDKWAEPEAELQTCHVRHMTTHNQSLQYRYDYNHHVSGGQSQTPRHSSTETAESSFLLSPSVLKALEGVHYIANHLRAEDADFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPFLAGMI
Inhibitor
Name:
BDBM86045
Synonyms:
NNEP
Type:
Small organic molecule
Emp. Form.:
C11H15N3
Mol. Mass.:
189.2569
SMILES:
Nc1ccc(cn1)[C@H]1CC2CCC1N2 |r,TLB:4:7:10.11:13|
Structure:
