Reaction Details
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Cholinergic receptor, nicotinic alpha 1
Ligand
BDBM86042
Substrate
n/a
Ki
3.2±n/a nM
Comments
PDSP_2905
Citation
Avalos, M; Parker, MJ; Maddox, FN; Carroll, FI; Luetje, CW Effects of pyridine ring substitutions on affinity, efficacy, and subtype selectivity of neuronal nicotinic receptor agonist epibatidine. J Pharmacol Exp Ther 302:1246-52 (2002) [PubMed] Article More Info.:
Target
Name:
Cholinergic receptor, nicotinic alpha 1
Synonyms:
Cholinergic, Nicotinic Alpha4Beta4 | acetylcholine receptor subunit alpha-1-A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52341.78
Organism:
Xenopus
Description:
Cholinergic, Nicotinic Alpha4Beta4 0 Xenopus::F6RLA9
Residue:
457
Sequence:
MDFSLTRLIFLFIAATLVFSSEDESRLINDLFKSYNKVVRPVKAFKDKVVVTLGLQLIQLINVDEVNQIVTTNVRLKQQWEDVHLKWNPEDYGGIKKVRISSGDIWRPDIVLYNNADGDFAIVQETKVLLDYTGKIIWTPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDGSLVVINPESDRPDLSNFMESGEWYMKDYRGWKHWVYYDCCPETPYLDITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPTDSGEKITLSVSVLLSLVVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVITSIVITVIVINTHHRSPSTHIMPQWLKKIFIETIPRVMFFSTMKRPAQDQQKKKIFTEDIDISDISGKLGPAAVKYQSPILKNPDVKSAIEGAKYIAETMKSDQESNKASEEWKFVAMVLDHLLLAVFMIVCIIGTLAIFAGRLIELHMQG
Inhibitor
Name:
BDBM86042
Synonyms:
NEP
Type:
Small organic molecule
Emp. Form.:
C11H14N2
Mol. Mass.:
174.2423
SMILES:
C1CC2NC1C[C@@H]2c1cccnc1 |r,TLB:7:6:0.1:3|
Structure:
