Reaction Details Report a problem with these data
Target
Cyclin-dependent kinase 2
Ligand
BDBM7393
Substrate
n/a
Ki
590±n/a nM
Comments
PDSP_6406
Citation
 Bain, J; McLauchlan, H; Elliott, M; Cohen, P The specificities of protein kinase inhibitors: an update. Biochem J 371:199-204 (2003) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM7393
Synonyms:
3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2-ylidene]-2,3-dihydro-1H-indol-2-one | CHEMBL397695 | Indirubin-3 -monoxime | Indirubin-3-monoxime | Indirubin-3monoxime | indirubin deriv. 7h
Type:
n/a
Emp. Form.:
C16H11N3O2
Mol. Mass.:
277.2774
SMILES:
O=Nc1c([nH]c2ccccc12)C1C(=O)Nc2ccccc12
Structure:
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