Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM277319
Substrate
n/a
Meas. Tech.
Human Sigma1 Receptor Radioligand Assay
pH
8±n/a
Ki
<500±n/a nM
Comments
extracted
Citation
 Almansa-Rosales, C Spiro-isoquinoline-3,4′-piperidine compounds having activity against pain US Patent  US10072008 Publication Date 9/11/2018 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM277319
Synonyms:
4-(2-(2-methyl-2,4-dihydro-1H-spiro[isoquinoline-3,4'-piperidine]-1'- | US10072008, Example 7
Type:
Small organic molecule
Emp. Form.:
C20H31N3O
Mol. Mass.:
329.4796
SMILES:
CN1Cc2ccccc2CC11CCN(CCN2CCOCC2)CC1
Structure:
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