Reaction Details Report a problem with these data
Target
Histamine receptor H3
Ligand
BDBM50158601
Substrate
n/a
Ki
4.27±n/a nM
Comments
PDSP_2991
Citation
 Esbenshade, TA; Krueger, KM; Miller, TR; Kang, CH; Denny, LI; Witte, DG; Yao, BB; Fox, GB; Faghih, R; Bennani, YL; Williams, M; Hancock, AA Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects. J Pharmacol Exp Ther 305:887-96 (2003) [PubMed]  Article 
Target
Name:
Histamine receptor H3
Synonyms:
HISTAMINE H3 | HRH3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
16901.59
Organism:
Dog
Description:
Q865E3
Residue:
147
Sequence:
FLLNLAISDFLVGAFCIPLYVPYVLTGRWPFSRGLCKLWLVVDYLLCTSSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVQKMVLVWVLAFLLYGPAILSWEHLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFN
  
Inhibitor
Name:
BDBM50158601
Synonyms:
A-317920 | CHEMBL361355 | Furan-2-carboxylic acid ((R)-2-{4-[3-(4-cyclopropanecarbonyl-phenoxy)-propyl]-piperazin-1-yl}-1-methyl-2-oxo-ethyl)-amide
Type:
Small organic molecule
Emp. Form.:
C25H31N3O5
Mol. Mass.:
453.5307
SMILES:
C[C@@H](NC(=O)c1ccco1)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1
Structure:
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