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Target
Arachidonate 12-lipoxygenase, 12R-type
Ligand
BDBM86086
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
4.43e+4± 7e+1 nM
Citation
 Ahmad, I; Chen, S; Peng, Y; Chen, S; Xu, L Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa. J Enzyme Inhib Med Chem 23:140-3 (2008) [PubMed]  Article 
Target
Name:
Arachidonate 12-lipoxygenase, 12R-type
Synonyms:
ALOX12B | LX12B_HUMAN | Lipoxygenase
Type:
Enzyme
Mol. Mass.:
80366.80
Organism:
Homo sapiens (Human)
Description:
O75342
Residue:
701
Sequence:
MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI
  
Inhibitor
Name:
BDBM86086
Synonyms:
Buddlejoside A, 1
Type:
Small organic molecule
Emp. Form.:
C22H26O11
Mol. Mass.:
466.4352
SMILES:
OCC1OC(O[C@@H]2OC=C[C@H]3[C@H](O)C=C(COC(=O)c4ccc(O)cc4)[C@@H]23)C(O)C(O)C1O |r,c:8,t:13|
Structure:
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