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Target
Arachidonate 12-lipoxygenase, 12R-type
Ligand
BDBM86088
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±0
Temperature
298.15±0 K
IC50
5.25e+4± 3e+1 nM
Citation
 Ahmad, I; Chen, S; Peng, Y; Chen, S; Xu, L Lipoxygenase inhibiting and antioxidant iridoids from Buddleja crispa. J Enzyme Inhib Med Chem 23:140-3 (2008) [PubMed]  Article 
Target
Name:
Arachidonate 12-lipoxygenase, 12R-type
Synonyms:
ALOX12B | LX12B_HUMAN | Lipoxygenase
Type:
Enzyme
Mol. Mass.:
80366.80
Organism:
Homo sapiens (Human)
Description:
O75342
Residue:
701
Sequence:
MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRIMEGIPTVELSGRKQHHCAPLCLLHFGPEGKMMPIAIQLSQTPGPDCPIFLPSDSEWDWLLAKTWVRYAEFYSHEAIAHLLETHLIAEAFCLALLRNLPMCHPLYKLLIPHTRYTVQINSIGRAVLLNEGGLSAKGMSLGVEGFAGVMVRALSELTYDSLYLPNDFVERGVQDLPGYYYRDDSLAVWNALEKYVTEIITYYYPSDAAVEGDPELQSWVQEIFKECLLGRESSGFPRCLRTVPELIRYVTIVIYTCSAKHAAVNTGQMEFTAWMPNFPASMRNPPIQTKGLTTLETFMDTLPDVKTTCITLLVLWTLSREPDDRRPLGHFPDIHFVEEAPRRSIEAFRQRLNQISHDIRQRNKCLPIPYYYLDPVLIENSISI
  
Inhibitor
Name:
BDBM86088
Synonyms:
Buddlejoside C, 3
Type:
Small organic molecule
Emp. Form.:
C21H32O9
Mol. Mass.:
428.4734
SMILES:
CC(C)CC(=O)OCC1=C[C@@H](O)[C@@H]2C=CC[C@H](OC3OC(CO)C(O)C(O)C3O)[C@H]12 |r,c:13,t:8|
Structure:
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