Reaction Details Report a problem with these data
Target
Retinol-binding protein 4
Ligand
BDBM249531
Substrate
n/a
Meas. Tech.
TR-FRET Assay for Retinol-induced RBP4-TTR Interaction
pH
7.5±n/a
IC50
13.8±n/a nM
Comments
extracted
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM249531
Synonyms:
US10072016, Compound 129 | US10407433, Compound 129 | US10913746, Compound 129 | US11649240, Compound 129 | US9434727, 129 | US9777010, Compound 129
Type:
Small organic molecule
Emp. Form.:
C22H22F8N4O
Mol. Mass.:
510.4235
SMILES:
Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CCN(CCC(F)(F)F)Cc12)C(F)(F)F
Structure:
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