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Target
Interferon gamma receptor 1
Ligand
BDBM277677
Substrate
n/a
Meas. Tech.
PBMC Cell Assay
IC50
31.8±n/a nM
Citation
 Fyfe, MC; Thom, SM Kinase inhibitors US Patent  US10072034 Publication Date 9/11/2018 
Target
Name:
Interferon gamma receptor 1
Synonyms:
CDw119 | IFN-gamma receptor 1 | IFN-gamma-R-alpha | IFN-gamma-R1 | IFNGR1 | INGR1_HUMAN | Interferon gamma receptor alpha-chain
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54381.75
Organism:
Homo sapiens (Human)
Description:
P15260
Residue:
489
Sequence:
MALLFLLPLVMQGVSRAEMGTADLGPSSVPTPTNVTIESYNMNPIVYWEYQIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVRVKARVGQKESAYAKSEEFAVCRDGKIGPPKLDIRKEEKQIMIDIFHPSVFVNGDEQEVDYDPETTCYIRVYNVYVRMNGSEIQYKILTQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS
  
Inhibitor
Name:
BDBM277677
Synonyms:
2-(2-(2-(3-((4-((4-(3-(5-(tert-Butyl)-2-methoxy)-3-(methylsulfonamido)phenyl)ureido-naphthalen-1-yl)oxy)pyridin-2-yl)amino-5-methoxyphenoxy)ethoxy)ethoxy)acetic acid | US10072034, Example 3
Type:
Small organic molecule
Emp. Form.:
C41H47N5O11S
Mol. Mass.:
817.904
SMILES:
COc1cc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc(OCCOCCOCC(O)=O)c1
Structure:
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