Reaction Details Report a problem with these data
Target
D(1A) dopamine receptor
Ligand
BDBM50117181
Substrate
n/a
Ki
33±n/a nM
Comments
PDSP_4942
Citation
Sit, SY; Xie, K; Jacutin-Porte, S; Boy, KM; Seanz, J; Taber, MT; Gulwadi, AG; Korpinen, CD; Burris, KD; Molski, TF; Ryan, E; Xu, C; Verdoorn, T; Johnson, G; Nichols, DE; Mailman, RB Synthesis and SAR exploration of dinapsoline analogues. Bioorg Med Chem 12:715-34 (2004) [PubMed] Article
More Info.:
Target
Name:
D(1A) dopamine receptor
Synonyms:
DOPAMINE D1 | DRD1_RAT | Dopamine D1 high | Dopamine D1 low | Dopamine receptor | Dopamine receptor D1 | Dopamine1-like | Drd1 | Drd1a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
49429.75
Organism:
RAT
Description:
P18901
Residue:
446
Sequence:
MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST
Inhibitor
Name:
BDBM50117181
Synonyms:
(S)-2,3,7,11b-Tetrahydro-1H-dibenzo[de,h]isoquinoline-8,9-diol | 2,3,7,11b-Tetrahydro-1H-dibenzo[de,h]isoquinoline-8,9-diol | CHEMBL124561 | Dinapsoline, (+/-) | Dinapsoline, (R)(+)
Type:
Small organic molecule
Emp. Form.:
C16H15NO2
Mol. Mass.:
253.2958
SMILES:
Oc1ccc2[C@@H]3CNCc4cccc(Cc2c1O)c34