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Target
Excitatory amino acid transporter 3
Ligand
BDBM86714
Substrate
n/a
Ki
1837±n/a nM
Comments
PDSP_6775
Citation
 Dunlop, J; McIlvain, HB; Carrick, TA; Jow, B; Lu, Q; Kowal, D; Lin, S; Greenfield, A; Grosanu, C; Fan, K; Petroski, R; Williams, J; Foster, A; Butera, J Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT2. Mol Pharmacol 68:974-82 (2005) [PubMed]  Article 
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM86714
Synonyms:
WAY 212922 | WAY-212922
Type:
Small organic molecule
Emp. Form.:
C18H15F3N2O3
Mol. Mass.:
364.3185
SMILES:
N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O
Structure:
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